Arming the Neighborhood

Arming antitumor T cells

The immune system can only prevent cancer if it recognizes and destroys precancerous cells. Antigenic targets of such an early immune response, however, have been elusive. Spisek et al. (page 831) now find that an embryonic stem cell marker is a bull's eye for immune cells in patients who have precancerous lesions but never develop multiple myeloma. Multiple myeloma is an incurable cancer that ...

Arming the pregnancy police: more outlandish concoctions?

Arming Cloud Services with Task Aspects

Our cloud services are losing too many battles to faults like software bugs, resource interference, and hardware failures. Many tools can help us win these battles: model checkers to verify, fault injection to find bugs, replay to debug, and many more. Unfortunately, tools are currently afterthoughts in cloud service designs that must either be tediously tangled into service implementations or ...

Molecular display technology using yeast--arming technology.

A technology to display proteins or peptides on living organisms has been developed over the last two decades. So-called "Molecular display (Arming) technology" or "Cell surface engineering" has been one of the important tools for analyzing and understanding protein function, or for screening of novel clones from libraries. In addition, it endows cells with novel abilities that cannot be added ...

Arming NK cells with enhanced antitumor activity

Natural killer (NK) cells hold great promise for adoptive cancer immunotherapy. The antitumor activity of NK cells can be enhanced by the transgene driven expression of chimeric antigen receptors that facilitate the selective recognition and killing of malignant cells. Recent data from our laboratory suggest that NK cells may similarly be "armed" against neoplastic cells by the expression of ca...